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Deletions of Immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia

BACKGROUND: Chronic myelogenous leukemia (CML) results from the neoplastic transformation of a haematopoietic stem cell. The hallmark genetic abnormality of CML is a chimeric BCR/ABL1 fusion gene resulting from the Philadelphia chromosome rearrangement t(9;22)(q34;q11). Clinical and laboratory studi...

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Detalles Bibliográficos
Autores principales:	Nacheva, Elisabeth P, Brazma, Diana, Virgili, Anna, Howard-Reeves, Julie, Chanalaris, Anastasios, Gancheva, Katya, Apostolova, Margarita, Valgañon, Mikel, Mazzullo, Helen, Grace, Colin
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822760/ https://www.ncbi.nlm.nih.gov/pubmed/20082691 http://dx.doi.org/10.1186/1471-2164-11-41

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