Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity

BACKGROUND: Neuropilin-1 (NRP1) is a non-tyrosine kinase receptor for vascular endothelial growth factor (VEGF) recently implicated in tumour functions. METHODS: In this study we used a specific antagonist of VEGF binding to the NRP1 b1 domain, EG3287, to investigate the functional roles of NRP1 in...

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Detalles Bibliográficos
Autores principales: Jia, H, Cheng, L, Tickner, M, Bagherzadeh, A, Selwood, D, Zachary, I
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822953/
https://www.ncbi.nlm.nih.gov/pubmed/20087344
http://dx.doi.org/10.1038/sj.bjc.6605539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822953/
https://www.ncbi.nlm.nih.gov/pubmed/20087344
http://dx.doi.org/10.1038/sj.bjc.6605539

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