Tissue regenerative delays and synthetic lethality in adult mice upon combined deletion of ATR and p53

Trp53 (p53) loss of function has previously been shown to rescue tissue maintenance and developmental defects resulting from DNA damage or DNA repair gene mutations1–12. Herein, we report that p53 deficiency significantly exacerbates tissue degeneration caused by mosaic deletion of the essential gen...

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Detalles Bibliográficos
Autores principales: Ruzankina, Yaroslava, Schoppy, David W., Asare, Amma, Clark, Carolyn E., Vonderheide, Robert H., Brown, Eric J.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823374/
https://www.ncbi.nlm.nih.gov/pubmed/19718024
http://dx.doi.org/10.1038/ng.441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823374/
https://www.ncbi.nlm.nih.gov/pubmed/19718024
http://dx.doi.org/10.1038/ng.441

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