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Tissue regenerative delays and synthetic lethality in adult mice upon combined deletion of ATR and p53
Trp53 (p53) loss of function has previously been shown to rescue tissue maintenance and developmental defects resulting from DNA damage or DNA repair gene mutations1–12. Herein, we report that p53 deficiency significantly exacerbates tissue degeneration caused by mosaic deletion of the essential gen...
Autores principales: | Ruzankina, Yaroslava, Schoppy, David W., Asare, Amma, Clark, Carolyn E., Vonderheide, Robert H., Brown, Eric J. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823374/ https://www.ncbi.nlm.nih.gov/pubmed/19718024 http://dx.doi.org/10.1038/ng.441 |
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