Endothelial Cell Processing and Alternatively Spliced Transcripts of Factor VIII: Potential Implications for Coagulation Cascades and Pulmonary Hypertension

BACKGROUND: Coagulation factor VIII (FVIII) deficiency leads to haemophilia A. Conversely, elevated plasma levels are a strong predictor of recurrent venous thromboemboli and pulmonary hypertension phenotypes in which in situ thromboses are implicated. Extrahepatic sources of plasma FVIII are implic...

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Detalles Bibliográficos
Autores principales: Shovlin, Claire L., Angus, Gillian, Manning, Richard A., Okoli, Grace N., Govani, Fatima S., Elderfield, Kay, Birdsey, Graeme M., Mollet, Inês G., Laffan, Michael A., Mauri, Francesco A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823490/
https://www.ncbi.nlm.nih.gov/pubmed/20174619
http://dx.doi.org/10.1371/journal.pone.0009154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823490/
https://www.ncbi.nlm.nih.gov/pubmed/20174619
http://dx.doi.org/10.1371/journal.pone.0009154

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