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Conformational Dynamics and Ligand Binding in the Multi-Domain Protein PDC109

PDC109 is a modular multi-domain protein with two fibronectin type II (Fn2) repeats joined by a linker. It plays a major role in bull sperm binding to the oviductal epithelium through its interactions with phosphorylcholines (PhCs), a head group of sperm cell membrane lipids. The crystal structure o...

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Detalles Bibliográficos
Autores principales: Kim, Hyun Jin, Choi, Moo Young, Kim, Hyung J., Llinás, Miguel
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823774/
https://www.ncbi.nlm.nih.gov/pubmed/20174627
http://dx.doi.org/10.1371/journal.pone.0009180