Nuclear Entry of Activated MAPK Is Restricted in Primary Ovarian and Mammary Epithelial Cells

BACKGROUND: The MAPK/ERK1/2 serine kinases are primary mediators of the Ras mitogenic signaling pathway. Phosphorylation by MEK activates MAPK/ERK in the cytoplasm, and phospho-ERK is thought to enter the nucleus readily to modulate transcription. PRINCIPAL FINDINGS: Here, however, we observe that i...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Elizabeth R., Cai, Kathy Qi, Smedberg, Jennifer L., Ribeiro, Melina M., Rula, Malgorzata E., Slater, Carolyn, Godwin, Andrew K., Xu, Xiang-Xi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823791/
https://www.ncbi.nlm.nih.gov/pubmed/20174585
http://dx.doi.org/10.1371/journal.pone.0009295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823791/
https://www.ncbi.nlm.nih.gov/pubmed/20174585
http://dx.doi.org/10.1371/journal.pone.0009295

Ejemplares similares