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Nuclear Entry of Activated MAPK Is Restricted in Primary Ovarian and Mammary Epithelial Cells

BACKGROUND: The MAPK/ERK1/2 serine kinases are primary mediators of the Ras mitogenic signaling pathway. Phosphorylation by MEK activates MAPK/ERK in the cytoplasm, and phospho-ERK is thought to enter the nucleus readily to modulate transcription. PRINCIPAL FINDINGS: Here, however, we observe that i...

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Detalles Bibliográficos
Autores principales:	Smith, Elizabeth R., Cai, Kathy Qi, Smedberg, Jennifer L., Ribeiro, Melina M., Rula, Malgorzata E., Slater, Carolyn, Godwin, Andrew K., Xu, Xiang-Xi
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823791/ https://www.ncbi.nlm.nih.gov/pubmed/20174585 http://dx.doi.org/10.1371/journal.pone.0009295

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