In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine

PURPOSE: To assess the potential inhibitory and inductive effects of azacitidine on cytochrome P450 isozymes in vitro. METHODS: The inhibitory effects of azacitidine on various CYP isozymes were determined in human liver microsomes. In addition, the ability of azacitidine to induce CYP enzymes in cu...

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Detalles Bibliográficos
Autores principales: Chen, Yong, Liu, Lisa, Laille, Eric, Kumar, Gondi, Surapaneni, Sekhar
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824119/
https://www.ncbi.nlm.nih.gov/pubmed/20119716
http://dx.doi.org/10.1007/s00280-010-1245-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824119/
https://www.ncbi.nlm.nih.gov/pubmed/20119716
http://dx.doi.org/10.1007/s00280-010-1245-9

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