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In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine

PURPOSE: To assess the potential inhibitory and inductive effects of azacitidine on cytochrome P450 isozymes in vitro. METHODS: The inhibitory effects of azacitidine on various CYP isozymes were determined in human liver microsomes. In addition, the ability of azacitidine to induce CYP enzymes in cu...

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Detalles Bibliográficos
Autores principales:	Chen, Yong, Liu, Lisa, Laille, Eric, Kumar, Gondi, Surapaneni, Sekhar
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2010
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824119/ https://www.ncbi.nlm.nih.gov/pubmed/20119716 http://dx.doi.org/10.1007/s00280-010-1245-9

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