Predicted Functions of MdmX in Fine-Tuning the Response of p53 to DNA Damage

Tumor suppressor protein p53 is regulated by two structurally homologous proteins, Mdm2 and MdmX. In contrast to Mdm2, MdmX lacks ubiquitin ligase activity. Although the essential interactions of MdmX are known, it is not clear how they function to regulate p53. The regulation of tumor suppressor p5...

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Detalles Bibliográficos
Autores principales: Kim, Sohyoung, Aladjem, Mirit I., McFadden, Geoffrey B., Kohn, Kurt W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824598/
https://www.ncbi.nlm.nih.gov/pubmed/20174603
http://dx.doi.org/10.1371/journal.pcbi.1000665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824598/
https://www.ncbi.nlm.nih.gov/pubmed/20174603
http://dx.doi.org/10.1371/journal.pcbi.1000665

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