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Modelling p-value distributions to improve theme-driven survival analysis of cancer transcriptome datasets

BACKGROUND: Theme-driven cancer survival studies address whether the expression signature of genes related to a biological process can predict patient survival time. Although this should ideally be achieved by testing two separate null hypotheses, current methods treat both hypotheses as one. The fi...

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Detalles Bibliográficos
Autores principales: Czwan, Esteban, Brors, Benedikt, Kipling, David
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824674/
https://www.ncbi.nlm.nih.gov/pubmed/20064243
http://dx.doi.org/10.1186/1471-2105-11-19