Linear Relationship between Deformability and Thermal Stability of 2′-O-Modified RNA Hetero Duplexes

[Image: see text] We describe the relationship between the experimentally determined melting temperatures of 2′-O-modified-RNA/RNA duplexes and their deformability estimated from molecular dynamics simulations. To clarify this relationship, we synthesized several fully modified oligoribonucleotides...

Descripción completa

Detalles Bibliográficos
Autores principales: Masaki, Yoshiaki, Miyasaka, Ryuta, Ohkubo, Akihiro, Seio, Kohji, Sekine, Mitsuo
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825091/
https://www.ncbi.nlm.nih.gov/pubmed/20108976
http://dx.doi.org/10.1021/jp909851j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825091/
https://www.ncbi.nlm.nih.gov/pubmed/20108976
http://dx.doi.org/10.1021/jp909851j

Ejemplares similares