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Linear Relationship between Deformability and Thermal Stability of 2′-O-Modified RNA Hetero Duplexes
[Image: see text] We describe the relationship between the experimentally determined melting temperatures of 2′-O-modified-RNA/RNA duplexes and their deformability estimated from molecular dynamics simulations. To clarify this relationship, we synthesized several fully modified oligoribonucleotides...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825091/ https://www.ncbi.nlm.nih.gov/pubmed/20108976 http://dx.doi.org/10.1021/jp909851j |