PI3Kγ Protects from Myocardial Ischemia and Reperfusion Injury through a Kinase-Independent Pathway

BACKGROUND: PI3Kγ functions in the immune compartment to promote inflammation in response to G-protein-coupled receptor (GPCR) agonists and PI3Kγ also acts within the heart itself both as a negative regulator of cardiac contractility and as a pro-survival factor. Thus, PI3Kγ has the potential to bot...

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Detalles Bibliográficos
Autores principales: Haubner, Bernhard J., Neely, G. Gregory, Voelkl, Jakob G. J., Damilano, Federico, Kuba, Keiji, Imai, Yumiko, Komnenovic, Vukoslav, Mayr, Agnes, Pachinger, Otmar, Hirsch, Emilio, Penninger, Josef M., Metzler, Bernhard
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825255/
https://www.ncbi.nlm.nih.gov/pubmed/20179753
http://dx.doi.org/10.1371/journal.pone.0009350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825255/
https://www.ncbi.nlm.nih.gov/pubmed/20179753
http://dx.doi.org/10.1371/journal.pone.0009350

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