A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

Obesity and insulin resistance are associated with deposition of triglycerides in tissues other than adipose tissue. Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content in...

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Detalles Bibliográficos
Autores principales: He, Shaoqing, McPhaul, Christopher, Li, John Zhong, Garuti, Rita, Kinch, Lisa, Grishin, Nick V., Cohen, Jonathan C., Hobbs, Helen H.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Lipids
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825465/
https://www.ncbi.nlm.nih.gov/pubmed/20034933
http://dx.doi.org/10.1074/jbc.M109.064501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825465/
https://www.ncbi.nlm.nih.gov/pubmed/20034933
http://dx.doi.org/10.1074/jbc.M109.064501

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