Cargando…

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

Obesity and insulin resistance are associated with deposition of triglycerides in tissues other than adipose tissue. Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content in...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Shaoqing, McPhaul, Christopher, Li, John Zhong, Garuti, Rita, Kinch, Lisa, Grishin, Nick V., Cohen, Jonathan C., Hobbs, Helen H.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Lipids
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825465/ https://www.ncbi.nlm.nih.gov/pubmed/20034933 http://dx.doi.org/10.1074/jbc.M109.064501

Ejemplares similares

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease
por: Huang, Yongcheng, et al.
Publicado: (2011)

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase
por: Chandak, Prakash G., et al.
Publicado: (2010)

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets
por: Mitsche, Matthew A., et al.
Publicado: (2018)

The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain
por: Heier, Christoph, et al.
Publicado: (2017)

Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins
por: Smagris, Eriks, et al.
Publicado: (2016)

PNPLA3, CGI‐58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice
por: Wang, Yang, et al.
Publicado: (2019)

Purification, Identification, and Cloning of Lysoplasmalogenase, the Enzyme That Catalyzes Hydrolysis of the Vinyl Ether Bond of Lysoplasmalogen
por: Wu, Lai-Chu, et al.
Publicado: (2011)

Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation
por: Pajed, Laura, et al.
Publicado: (2019)

A Peptide Derived from G(0)/G(1) Switch Gene 2 Acts as Noncompetitive Inhibitor of Adipose Triglyceride Lipase
por: Cerk, Ines K., et al.
Publicado: (2014)

Triglycerides and HDL Cholesterol: Stars or second leads in diabetes?
por: Bitzur, Rafael, et al.
Publicado: (2009)

Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain
por: Saeed, Ahmed A., et al.
Publicado: (2014)

Homocysteine regulates fatty acid and lipid metabolism in yeast
por: Visram, Myriam, et al.
Publicado: (2018)

Serum lipoprotein–derived fatty acids regulate hypoxia-inducible factor
por: Shao, Wei, et al.
Publicado: (2021)

Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling
por: Hofer, Peter, et al.
Publicado: (2015)

The CDK9–cyclin T1 complex mediates saturated fatty acid–induced vascular calcification by inducing expression of the transcription factor CHOP
por: Shiozaki, Yuji, et al.
Publicado: (2018)

Randomized controlled study of the effect of a butter naturally enriched in trans fatty acids on blood lipids in healthy women(1)(2)(3)
por: Lacroix, Émilie, et al.
Publicado: (2012)

Lipids in the Wrong Place: Visceral Fat and Nonalcoholic Steatohepatitis
por: Perseghin, Gianluca
Publicado: (2011)

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
por: Lindén, Daniel, et al.
Publicado: (2019)

The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
por: Stojkovic, Ivana A., et al.
Publicado: (2014)

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
por: BasuRay, Soumik, et al.
Publicado: (2017)

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
por: Smagris, Eriks, et al.
Publicado: (2015)

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
por: Romeo, Stefano, et al.
Publicado: (2008)

Erratum to: The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
por: Stojkovic, Ivana A., et al.
Publicado: (2016)

Identification of Plant-like Galactolipids in Chromera velia, a Photosynthetic Relative of Malaria Parasites
por: Botté, Cyrille Y., et al.
Publicado: (2011)

Antioxidant-rich spice added to hamburger meat during cooking results in reduced meat, plasma, and urine malondialdehyde concentrations(1)(2)(3)(4)
por: Li, Zhaoping, et al.
Publicado: (2010)

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid
por: Isobe, Yosuke, et al.
Publicado: (2012)

Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme
por: Lamour, Nadia F., et al.
Publicado: (2011)

Functional and Topological Analysis of Yeast Acyl-CoA:Diacylglycerol Acyltransferase 2, an Endoplasmic Reticulum Enzyme Essential for Triacylglycerol Biosynthesis
por: Liu, Qin, et al.
Publicado: (2011)

Lipid Raft Association and Cholesterol Sensitivity of P2X1-4 Receptors for ATP: CHIMERAS AND POINT MUTANTS IDENTIFY INTRACELLULAR AMINO-TERMINAL RESIDUES INVOLVED IN LIPID REGULATION OF P2X1 RECEPTORS
por: Allsopp, Rebecca C., et al.
Publicado: (2010)

Ataxin-1 Poly(Q)-induced Proteotoxic Stress and Apoptosis Are Attenuated in Neural Cells by Docosahexaenoic Acid-derived Neuroprotectin D1
por: Calandria, Jorgelina M., et al.
Publicado: (2012)

Phospholipid-esterified Eicosanoids Are Generated in Agonist-activated Human Platelets and Enhance Tissue Factor-dependent Thrombin Generation
por: Thomas, Christopher P., et al.
Publicado: (2010)

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response
por: Ariyama, Hiroyuki, et al.
Publicado: (2010)

Metabolic and Transcriptional Responses of Glycerolipid Pathways to a Perturbation of Glycerol 3-Phosphate Metabolism in Arabidopsis
por: Shen, Wenyun, et al.
Publicado: (2010)

Triacylglycerol Accumulation Activates the Mitochondrial Apoptosis Pathway in Macrophages
por: Aflaki, Elma, et al.
Publicado: (2011)

Kdo(2)-Lipid A, a TLR4-specific Agonist, Induces de Novo Sphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy
por: Sims, Kacee, et al.
Publicado: (2010)

Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation
por: Kosenko, Tanja, et al.
Publicado: (2013)

Identification of a Mammalian-type Phosphatidylglycerophosphate Phosphatase in the Eubacterium Rhodopirellula baltica
por: Teh, Phildrich G., et al.
Publicado: (2013)

Conformational Plasticity and Ligand Binding of Bacterial Monoacylglycerol Lipase
por: Rengachari, Srinivasan, et al.
Publicado: (2013)

Rapid Production of Platelet-activating Factor Is Induced by Protein Kinase Cα-mediated Phosphorylation of Lysophosphatidylcholine Acyltransferase 2 Protein
por: Morimoto, Ryo, et al.
Publicado: (2014)

High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F(2α) concentrations relative to a control high–oleic acid meal: a randomized controlled trial(1)(2)(3)(4)
por: Purcell, Robert, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_309vsrtf8hmfj7udo04frf4ku3