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PrP(Sc )accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases
Prion diseases are disorders of protein conformation in which PrP(C), the normal cellular conformer, is converted to an abnormal, protease-resistant conformer rPrP(Sc). Approximately 80% of rPrP(Sc )accumulates in neuronal plasma membranes where it changes their physical properties and profoundly af...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825502/ https://www.ncbi.nlm.nih.gov/pubmed/20205843 http://dx.doi.org/10.1186/1750-1326-5-6 |