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Voltage-Dependent Gating in a “Voltage Sensor-Less” Ion Channel

The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity. We have identified a remarkable point mutation that confers significant voltage de...

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Detalles Bibliográficos
Autores principales: Kurata, Harley T., Rapedius, Markus, Kleinman, Marc J., Baukrowitz, Thomas ., Nichols, Colin G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826373/
https://www.ncbi.nlm.nih.gov/pubmed/20208975
http://dx.doi.org/10.1371/journal.pbio.1000315