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Voltage-Dependent Gating in a “Voltage Sensor-Less” Ion Channel
The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity. We have identified a remarkable point mutation that confers significant voltage de...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826373/ https://www.ncbi.nlm.nih.gov/pubmed/20208975 http://dx.doi.org/10.1371/journal.pbio.1000315 |