Designing Inhibitors of M2 Proton Channel against H1N1 Swine Influenza Virus

BACKGROUND: M2 proton channel of H1N1 influenza A virus is the target protein of anti-flu drugs amantadine and rimantadine. However, the two once powerful adamantane-based drugs lost their 90% bioactivity because of mutations of virus in recent twenty years. The NMR structure of the M2 channel prote...

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Detalles Bibliográficos
Autores principales: Du, Qi-Shi, Huang, Ri-Bo, Wang, Shu-Qing, Chou, Kuo-Chen
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826421/
https://www.ncbi.nlm.nih.gov/pubmed/20186344
http://dx.doi.org/10.1371/journal.pone.0009388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826421/
https://www.ncbi.nlm.nih.gov/pubmed/20186344
http://dx.doi.org/10.1371/journal.pone.0009388

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