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Designing Inhibitors of M2 Proton Channel against H1N1 Swine Influenza Virus
BACKGROUND: M2 proton channel of H1N1 influenza A virus is the target protein of anti-flu drugs amantadine and rimantadine. However, the two once powerful adamantane-based drugs lost their 90% bioactivity because of mutations of virus in recent twenty years. The NMR structure of the M2 channel prote...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826421/ https://www.ncbi.nlm.nih.gov/pubmed/20186344 http://dx.doi.org/10.1371/journal.pone.0009388 |