The Octarepeat Region of the Prion Protein Is Conformationally Altered in PrP(Sc)

BACKGROUND: Prion diseases are fatal neurodegenerative disorders characterized by misfolding and aggregation of the normal prion protein PrP(C). Little is known about the details of the structural rearrangement of physiological PrP(C) into a still-elusive disease-associated conformation termed PrP(S...

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Detalles Bibliográficos
Autores principales: Yam, Alice Y., Gao, Carol Man, Wang, Xuemei, Wu, Ping, Peretz, David
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827544/
https://www.ncbi.nlm.nih.gov/pubmed/20195363
http://dx.doi.org/10.1371/journal.pone.0009316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827544/
https://www.ncbi.nlm.nih.gov/pubmed/20195363
http://dx.doi.org/10.1371/journal.pone.0009316

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