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The Octarepeat Region of the Prion Protein Is Conformationally Altered in PrP(Sc)
BACKGROUND: Prion diseases are fatal neurodegenerative disorders characterized by misfolding and aggregation of the normal prion protein PrP(C). Little is known about the details of the structural rearrangement of physiological PrP(C) into a still-elusive disease-associated conformation termed PrP(S...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827544/ https://www.ncbi.nlm.nih.gov/pubmed/20195363 http://dx.doi.org/10.1371/journal.pone.0009316 |