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Optimal In Silico Target Gene Deletion through Nonlinear Programming for Genetic Engineering
BACKGROUND: Optimal selection of multiple regulatory genes, known as targets, for deletion to enhance or suppress the activities of downstream genes or metabolites is an important problem in genetic engineering. Such problems become more feasible to address in silico due to the availability of more...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827548/ https://www.ncbi.nlm.nih.gov/pubmed/20195367 http://dx.doi.org/10.1371/journal.pone.0009331 |