Hyperglycemia Impairs Proteasome Function by Methylglyoxal

OBJECTIVE: The ubiquitin-proteasome system is the main degradation machinery for intracellularly altered proteins. Hyperglycemia has been shown to increase intracellular levels of the reactive dicarbonyl methylglyoxal (MGO) in cells damaged by diabetes, resulting in modification of proteins and alte...

Descripción completa

Detalles Bibliográficos
Autores principales: Queisser, Markus A., Yao, Dachun, Geisler, Sven, Hammes, Hans-Peter, Lochnit, Günter, Schleicher, Erwin D., Brownlee, Michael, Preissner, Klaus T.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828656/
https://www.ncbi.nlm.nih.gov/pubmed/20009088
http://dx.doi.org/10.2337/db08-1565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828656/
https://www.ncbi.nlm.nih.gov/pubmed/20009088
http://dx.doi.org/10.2337/db08-1565

Ejemplares similares