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Hyperglycemia Impairs Proteasome Function by Methylglyoxal
OBJECTIVE: The ubiquitin-proteasome system is the main degradation machinery for intracellularly altered proteins. Hyperglycemia has been shown to increase intracellular levels of the reactive dicarbonyl methylglyoxal (MGO) in cells damaged by diabetes, resulting in modification of proteins and alte...
Autores principales: | Queisser, Markus A., Yao, Dachun, Geisler, Sven, Hammes, Hans-Peter, Lochnit, Günter, Schleicher, Erwin D., Brownlee, Michael, Preissner, Klaus T. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828656/ https://www.ncbi.nlm.nih.gov/pubmed/20009088 http://dx.doi.org/10.2337/db08-1565 |
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