Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster

Endocytosis of the transmembrane ligands Delta (Dl) and Serrate (Ser) is required for the proper activation of Notch receptors. The E3 ubiquitin ligases Mindbomb1 (Mib1) and Neuralized (Neur) regulate the ubiquitination of Dl and Ser and thereby promote both ligand endocytosis and Notch receptor act...

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Detalles Bibliográficos
Autores principales: Hamel, Sophie, Fantini, Jacques, Schweisguth, François
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828914/
https://www.ncbi.nlm.nih.gov/pubmed/20176925
http://dx.doi.org/10.1083/jcb.200907116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828914/
https://www.ncbi.nlm.nih.gov/pubmed/20176925
http://dx.doi.org/10.1083/jcb.200907116

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