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Numb Independently Antagonizes Sanpodo Membrane Targeting and Notch Signaling in Drosophila Sensory Organ Precursor Cells

In Drosophila, mitotic neural progenitor cells asymmetrically segregate the cell fate determinant Numb in order to block Notch signaling in only one of the two daughter cells. Sanpodo, a membrane protein required for Notch signaling in asymmetrically dividing cells, is sequestered from the plasma me...

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Detalles Bibliográficos
Autores principales: Tong, Xin, Zitserman, Diana, Serebriiskii, Ilya, Andrake, Mark, Dunbrack, Roland, Roegiers, Fabrice
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828966/
https://www.ncbi.nlm.nih.gov/pubmed/20053677
http://dx.doi.org/10.1091/mbc.E09-09-0831