Cargando…

HIV Controller CD4+ T Cells Respond to Minimal Amounts of Gag Antigen Due to High TCR Avidity

HIV controllers are rare individuals who spontaneously control HIV replication in the absence of antiretroviral treatment. Emerging evidence indicates that HIV control is mediated through very active cellular immune responses, though how such responses can persist over time without immune exhaustion...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vingert, Benoît, Perez-Patrigeon, Santiago, Jeannin, Patricia, Lambotte, Olivier, Boufassa, Faroudy, Lemaître, Fabrice, Kwok, William W., Theodorou, Ioannis, Delfraissy, Jean-François, Thèze, Jacques, Chakrabarti, Lisa A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829066/ https://www.ncbi.nlm.nih.gov/pubmed/20195518 http://dx.doi.org/10.1371/journal.ppat.1000780

Ejemplares similares

P16-45. High avidity CD4+ T cell response directed to an immunodominant Gag epitope in HIV controllers: an ANRS EP36 study
por: Vingert, B, et al.
Publicado: (2009)

High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers
por: Lambotte, Olivier, et al.
Publicado: (2013)

The Quest for the Best: How TCR Affinity, Avidity, and Functional Avidity Affect TCR-Engineered T-Cell Antitumor Responses
por: Campillo-Davo, Diana, et al.
Publicado: (2020)

CD4 Dynamics over a 15 Year-Period among HIV Controllers Enrolled in the ANRS French Observatory
por: Boufassa, Faroudy, et al.
Publicado: (2011)

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity
por: Azzam, Hala S., et al.
Publicado: (1998)

Distinct Genetic Loci Control Plasma HIV-RNA and Cellular HIV-DNA Levels in HIV-1 Infection: The ANRS Genome Wide Association 01 Study
por: Dalmasso, Cyril, et al.
Publicado: (2008)

Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain
por: Kuball, Jürgen, et al.
Publicado: (2009)

Antiretroviral therapy for HIV controllers: Reasons for initiation and outcomes in the French ANRS-CO21 CODEX cohort
por: Plaçais, Léo, et al.
Publicado: (2021)

Avidity optimization of a MAGE‐A1‐specific TCR with somatic hypermutation
por: Bassan, David, et al.
Publicado: (2021)

Overall avidity declines in TCR repertoires during latent CMV but not EBV infection
por: Couturaud, Barbara, et al.
Publicado: (2023)

Non-AIDS-Defining Events in Human Immunodeficiency Virus Controllers Versus Antiretroviral Therapy–Controlled Patients: A Cohort Collaboration From the French National Agency for Research on AIDS CO21 (CODEX) and CO06 (PRIMO) Cohorts
por: Manto, Carmelite, et al.
Publicado: (2023)

Determination of the relative amounts of Gag and Pol proteins in foamy virus particles
por: Cartellieri, Marc, et al.
Publicado: (2005)

Analysis of NKp30/NCR3 isoforms in untreated HIV-1-infected patients from the ANRS SEROCO cohort
por: Prada, Nicole, et al.
Publicado: (2013)

The coordination of unprotonated peptide tertiary structure as a metric of pMHC–TCR functional avidity
por: Antipas, Georgios S.E., et al.
Publicado: (2015)

Immunologic and Virologic Progression in HIV Controllers: The Role of Viral “Blips” and Immune Activation in the ANRS CO21 CODEX Study
por: Noel, Nicolas, et al.
Publicado: (2015)

A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level
por: Canouï, Etienne, et al.
Publicado: (2017)

Age‐Related Deterioration of Bone Toughness Is Related to Diminishing Amount of Matrix Glycosaminoglycans (GAGs)
por: Wang, Xiaodu, et al.
Publicado: (2018)

Potential Role for HIV-Specific CD38(−)/HLA-DR(+) CD8(+) T Cells in Viral Suppression and Cytotoxicity in HIV Controllers
por: Hua, Stéphane, et al.
Publicado: (2014)

Potentiating the Antitumor Activity of Cytotoxic T Cells via the Transmembrane Domain of IGSF4 That Increases TCR Avidity
por: Kim, Hye-Ran, et al.
Publicado: (2021)

PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses
por: Anderson, Warren, et al.
Publicado: (2023)

Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions
Publicado: (1996)

Detectable HIV-RNA in semen of HIV controllers
por: Chaix, Marie-Laure, et al.
Publicado: (2017)

A Pilot Study of the Humoral Response Against the AntiSense Protein (ASP) in HIV-1-Infected Patients
por: Savoret, Juliette, et al.
Publicado: (2020)

CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells
por: Nakatsugawa, Munehide, et al.
Publicado: (2016)

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8(+) T Cells
por: Pearson, James A., et al.
Publicado: (2016)

New insights into retroviral Gag–Gag and Gag–membrane interactions
por: Maldonado, José O., et al.
Publicado: (2014)

Blunted Response to Combination Antiretroviral Therapy in HIV Elite Controllers: An International HIV Controller Collaboration
por: Boufassa, Faroudy, et al.
Publicado: (2014)

In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control
por: Trémeaux, Pauline, et al.
Publicado: (2023)

TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines
por: Jordan, Kimberly R., et al.
Publicado: (2012)

Responding to the humanitarian crisis of the war in Ukraine with lessons from COVID-19
por: Archard, David, et al.
Publicado: (2022)

The quantum chemical causality of pMHC-TCR biological avidity: Peptide atomic coordination data and the electronic state of agonist N termini
por: Antipas, Georgios S.E., et al.
Publicado: (2015)

Dynamics in HIV‐DNA levels over time in HIV controllers
por: Avettand‐Fenoel, Véronique, et al.
Publicado: (2019)

Avid Editing
por: Kauffmann, Sam, et al.
Publicado: (2017)

An Avid Imitator
por: Farmakiotis, Dimitrios, et al.
Publicado: (2016)

Characterization of the TCR β Chain Repertoire in Peripheral Blood from Hepatitis B Vaccine Responders and Non-Responders
por: Yang, Jiezuan, et al.
Publicado: (2022)

Editing with Avid Media Composer 5: the official Avid guide.
por: Kennedy, Ashley
Publicado: (2010)

Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice
por: Saha, Ipsita, et al.
Publicado: (2021)

GagCM9-Specific CD8(+) T Cells Expressing Limited Public TCR Clonotypes Do Not Suppress SIV Replication In Vivo
por: Vojnov, Lara, et al.
Publicado: (2011)

Phenotypic characterization of virological failure following lopinavir/ritonavir monotherapy using full-length gag–protease genes
por: Sutherland, Katherine A., et al.
Publicado: (2014)

Gag and Stroke
por: Smithard, David
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_rmttpriqv5hmld87aka88qec0r