A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma

BACKGROUND: DNA-methyltransferase (DNMT)-3A plays an important role in the development of embryogenesis and the generation of aberrant methylation in carcinogenesis. The aim of this study was to investigate the role of a DNMT3A promoter genetic variant on its transcriptional activity and to evaluate...

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Detalles Bibliográficos
Autores principales: Fan, Hong, Liu, Dongsheng, Qiu, Xuemei, Qiao, Fengchang, Wu, Qingxiang, Su, Xianwei, Zhang, Feng, Song, Yunwei, Zhao, Zhujiang, Xie, Wei
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829483/
https://www.ncbi.nlm.nih.gov/pubmed/20128888
http://dx.doi.org/10.1186/1741-7015-8-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829483/
https://www.ncbi.nlm.nih.gov/pubmed/20128888
http://dx.doi.org/10.1186/1741-7015-8-12

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