Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent

BACKGROUND: Onconase represents a new class of RNA-damaging drugs. Mechanistically, Onconase is thought to internalize, where it degrades intracellular RNAs such as tRNA and double-stranded RNA, and thereby suppresses protein synthesis. However, there may be additional or alternative mechanism(s) of...

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Detalles Bibliográficos
Autores principales: Altomare, Deborah A, Rybak, Susanna M, Pei, Jianming, Maizel, Jacob V, Cheung, Mitchell, Testa, Joseph R, Shogen, Kuslima
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829496/
https://www.ncbi.nlm.nih.gov/pubmed/20137089
http://dx.doi.org/10.1186/1471-2407-10-34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829496/
https://www.ncbi.nlm.nih.gov/pubmed/20137089
http://dx.doi.org/10.1186/1471-2407-10-34

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