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Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent
BACKGROUND: Onconase represents a new class of RNA-damaging drugs. Mechanistically, Onconase is thought to internalize, where it degrades intracellular RNAs such as tRNA and double-stranded RNA, and thereby suppresses protein synthesis. However, there may be additional or alternative mechanism(s) of...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829496/ https://www.ncbi.nlm.nih.gov/pubmed/20137089 http://dx.doi.org/10.1186/1471-2407-10-34 |