HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

Histone deacetylase 1 (HDAC1) is a nuclear enzyme involved in transcriptional repression. We report here that cytosolic HDAC1 is detected in damaged axons in brains of human patients with Multiple Sclerosis and of mice with cuprizone-induced demyelination, ex vivo models of demyelination and in cult...

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Detalles Bibliográficos
Autores principales: Kim, Jin Young, Shen, Siming, Dietz, Karen, He, Ye, Howell, Owain, Reynolds, Richard, Casaccia, Patrizia
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829989/
https://www.ncbi.nlm.nih.gov/pubmed/20037577
http://dx.doi.org/10.1038/nn.2471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829989/
https://www.ncbi.nlm.nih.gov/pubmed/20037577
http://dx.doi.org/10.1038/nn.2471

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