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Modeling of replicative senescence in hematopoietic development

Hematopoietic stem cells (HSC) give rise to an enormous number of blood cells throughout our life. In contrast their number of cell divisions preceding senescence is limited underin vitro culture conditions. Here we consider the question whether HSC can rejuvenate indefinitely or if the number of ce...

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Detalles Bibliográficos
Autores principales: Marciniak-Czochra, Anna, Stiehl, Thomas, Wagner, Wolfgang
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830082/
https://www.ncbi.nlm.nih.gov/pubmed/20195386