Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

The severe acute respiratory syndrome coronavirus (SARS-CoV) caused substantial morbidity and mortality in 2002–2003. Deletion of the envelope (E) protein modestly diminished virus growth in tissue culture but abrogated virulence in animals. Here, we show that immunization with rSARS-CoV-ΔE or SARS-...

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Detalles Bibliográficos
Autores principales: Netland, Jason, DeDiego, Marta L., Zhao, Jincun, Fett, Craig, Álvarez, Enrique, Nieto-Torres, José L., Enjuanes, Luis, Perlman, Stanley
Formato: Texto
Lenguaje:English
Publicado: Elsevier Inc. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830353/
https://www.ncbi.nlm.nih.gov/pubmed/20110095
http://dx.doi.org/10.1016/j.virol.2010.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830353/
https://www.ncbi.nlm.nih.gov/pubmed/20110095
http://dx.doi.org/10.1016/j.virol.2010.01.004

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