Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca(2+) and AMP
Activation of AMPK (AMP-activated protein kinase) by phosphorylation at Thr(172) is catalysed by at least two distinct upstream kinases, i.e. the tumour suppressor LKB1, and CaMKKβ (Ca(2+)/calmodulin-dependent protein kinase kinase-β). The sequence around Thr(172) is highly conserved between the two...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830670/ https://www.ncbi.nlm.nih.gov/pubmed/19958286 http://dx.doi.org/10.1042/BJ20091372 |