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Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca(2+) and AMP

Activation of AMPK (AMP-activated protein kinase) by phosphorylation at Thr(172) is catalysed by at least two distinct upstream kinases, i.e. the tumour suppressor LKB1, and CaMKKβ (Ca(2+)/calmodulin-dependent protein kinase kinase-β). The sequence around Thr(172) is highly conserved between the two...

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Detalles Bibliográficos
Autores principales:	Fogarty, Sarah, Hawley, Simon A., Green, Kevin A., Saner, Nazan, Mustard, Kirsty J., Hardie, D. Grahame
Formato:	Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830670/ https://www.ncbi.nlm.nih.gov/pubmed/19958286 http://dx.doi.org/10.1042/BJ20091372

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