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Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation
Rab GTPases are molecular switches that orchestrate vesicular trafficking, maturation and fusion by cycling between an active, GTP-bound form, and an inactive, GDP-bound form. The activity cycle is coupled to GTP hydrolysis and is tightly controlled by regulatory proteins. Missense mutations of the...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830827/ https://www.ncbi.nlm.nih.gov/pubmed/20028791 http://dx.doi.org/10.1093/hmg/ddp567 |