Jade-1 inhibits Wnt signaling by ubiquitinating β-catenin and mediates Wnt pathway inhibition by pVHL

The von Hippel-Lindau protein pVHL suppresses renal tumorigenesis in part by promoting degradation of hypoxia-inducible HIF-alpha transcription factors1, and additional mechanisms have been proposed2. pVHL also stabilizes plant homeodomain (PHD) protein Jade-1, which is a candidate renal tumor suppr...

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Detalles Bibliográficos
Autores principales: Chitalia, Vipul C., Foy, Rebecca L., Bachschmid, Markus M., Zeng, Liling, Panchenko, Maria V., Zhou, Mina I., Bharti, Ajit, Seldin, David C., Lecker, Stewart H., Dominguez, Isabel, Cohen, Herbert T.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830866/
https://www.ncbi.nlm.nih.gov/pubmed/18806787
http://dx.doi.org/10.1038/ncb1781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830866/
https://www.ncbi.nlm.nih.gov/pubmed/18806787
http://dx.doi.org/10.1038/ncb1781

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