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From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
The Ras-dependent Raf/MEK/ERK1/2 mitogen-activated protein (MAP) kinase signaling pathway is a major regulator of cell proliferation and survival. Not surprisingly, hyperactivation of this pathway is frequently observed in human malignancies as a result of aberrant activation of receptor tyrosine ki...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830959/ https://www.ncbi.nlm.nih.gov/pubmed/20149254 http://dx.doi.org/10.1186/1756-8722-3-8 |