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Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage
Ionising radiation induces clustered DNA damage sites which pose a severe challenge to the cell’s repair machinery, particularly base excision repair. To date, most studies have focussed on two-lesion clusters. We have designed synthetic oligonucleotides to give a variety of three-lesion clusters co...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831305/ https://www.ncbi.nlm.nih.gov/pubmed/19965771 http://dx.doi.org/10.1093/nar/gkp1070 |