Cargando…
Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage
Ionising radiation induces clustered DNA damage sites which pose a severe challenge to the cell’s repair machinery, particularly base excision repair. To date, most studies have focussed on two-lesion clusters. We have designed synthetic oligonucleotides to give a variety of three-lesion clusters co...
Autores principales: | Eccles, Laura J., Lomax, Martine E., O’Neill, Peter |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831305/ https://www.ncbi.nlm.nih.gov/pubmed/19965771 http://dx.doi.org/10.1093/nar/gkp1070 |
Ejemplares similares
-
Disruption of PARP1 function inhibits base excision repair of a sub-set of DNA lesions
por: Reynolds, Pamela, et al.
Publicado: (2015) -
Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic
por: Bellon, Sophie, et al.
Publicado: (2009) -
UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages
por: Greinert, R., et al.
Publicado: (2012) -
Rad10 exhibits lesion-dependent genetic requirements for recruitment to DNA double-strand breaks in Saccharomyces cerevisiae
por: Moore, Destaye M., et al.
Publicado: (2009) -
Short inverted repeats contribute to localized mutability in human somatic cells
por: Zou, Xueqing, et al.
Publicado: (2017)