Cargando…

Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage

Ionising radiation induces clustered DNA damage sites which pose a severe challenge to the cell’s repair machinery, particularly base excision repair. To date, most studies have focussed on two-lesion clusters. We have designed synthetic oligonucleotides to give a variety of three-lesion clusters co...

Descripción completa

Detalles Bibliográficos
Autores principales: Eccles, Laura J., Lomax, Martine E., O’Neill, Peter
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831305/
https://www.ncbi.nlm.nih.gov/pubmed/19965771
http://dx.doi.org/10.1093/nar/gkp1070

Ejemplares similares