Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their Saccharomyces cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid str...

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Detalles Bibliográficos
Autores principales: Johnson, Jay E., Cao, Kajia, Ryvkin, Paul, Wang, Li-San, Johnson, F. Brad
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831322/
https://www.ncbi.nlm.nih.gov/pubmed/19966276
http://dx.doi.org/10.1093/nar/gkp1103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831322/
https://www.ncbi.nlm.nih.gov/pubmed/19966276
http://dx.doi.org/10.1093/nar/gkp1103

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