Cargando…

Personalized medicine in psoriasis: developing a genomic classifier to predict histological response to Alefacept

BACKGROUND: Alefacept treatment is highly effective in a select group patients with moderate-to-severe psoriasis, and is an ideal candidate to develop systems to predict who will respond to therapy. A clinical trial of 22 patients with moderate to severe psoriasis treated with alefacept was conducte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suárez-Fariñas, Mayte, Shah, Kejal R, Haider, Asifa S, Krueger, James G, Lowes, Michelle A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831811/ https://www.ncbi.nlm.nih.gov/pubmed/20152045 http://dx.doi.org/10.1186/1471-5945-10-1

Ejemplares similares

Evaluation of the Psoriasis Transcriptome across Different Studies by Gene Set Enrichment Analysis (GSEA)
por: Suárez-Fariñas, Mayte, et al.
Publicado: (2010)

The safety and efficacy of alefacept in the treatment of chronic plaque psoriasis
por: Jenneck, Claudia, et al.
Publicado: (2007)

Can We Repurpose FDA-Approved Alefacept to Diminish the HIV Reservoir?
por: Zaidi, Asifa, et al.
Publicado: (2015)

Meta-Analysis Derived (MAD) Transcriptome of Psoriasis Defines the “Core” Pathogenesis of Disease
por: Tian, Suyan, et al.
Publicado: (2012)

Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
por: Chamian, Francesca, et al.
Publicado: (2007)

Histological Stratification of Thick and Thin Plaque Psoriasis Explores Molecular Phenotypes with Clinical Implications
por: Kim, Jaehwan, et al.
Publicado: (2015)

"Harshlighting" small blemishes on microarrays
por: Suárez-Fariñas, Mayte, et al.
Publicado: (2005)

Post-Therapeutic Relapse of Psoriasis after CD11a Blockade Is Associated with T Cells and Inflammatory Myeloid DCs
por: Johnson-Huang, Leanne M., et al.
Publicado: (2012)

IL-17 and TNF synergistically modulate cytokine expression while suppressing melanogenesis: potential relevance to psoriasis
por: Wang, Claire Q.F., et al.
Publicado: (2013)

Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis
por: Suárez-Fariñas, Mayte, et al.
Publicado: (2012)

Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis
por: Ruano, Juan, et al.
Publicado: (2016)

Transcriptional profiling of psoriasis using RNA-seq reveals previously unidentified differentially expressed genes
por: Jabbari, Ali, et al.
Publicado: (2011)

A single intradermal injection of IFN-γ induces an inflammatory state in both non-lesional psoriatic and healthy skin
por: Johnson-Huang, Leanne M., et al.
Publicado: (2012)

Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions
por: Gulati, Nicholas, et al.
Publicado: (2015)

ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES
por: Weaver, T.A., et al.
Publicado: (2009)

CARD14 Expression in Dermal Endothelial Cells in Psoriasis
por: Harden, Jamie L., et al.
Publicado: (2014)

Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris
por: Bissonnette, Robert, et al.
Publicado: (2016)

Correction: Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris
por: Bissonnette, Robert, et al.
Publicado: (2016)

Molecular Phenotyping Small (Asian) versus Large (Western) Plaque Psoriasis Shows Common Activation of IL-17 Pathway Genes, but Different Regulatory Gene Sets
por: Kim, Jaehwan, et al.
Publicado: (2016)

TREM-1 as a Potential Therapeutic Target in Psoriasis
por: Hyder, Luke A., et al.
Publicado: (2013)

Creation of differentiation-specific genomic maps of human epidermis through laser capture microdissection
por: Gulati, Nicholas, et al.
Publicado: (2013)

Dominant Th1 and minimal Th17 skewing in discoid lupus revealed by transcriptomic comparison with psoriasis
por: Jabbari, Ali, et al.
Publicado: (2013)

GEE-TGDR: A Longitudinal Feature Selection Algorithm and Its Application to lncRNA Expression Profiles for Psoriasis Patients Treated with Immune Therapies
por: Tian, Suyan, et al.
Publicado: (2021)

Alefacept treatment in psoriatic arthritis: reduction of the synovial inflammatory infiltrate and improvement of clinical signs of arthritis
por: Kraan, MC, et al.
Publicado: (2002)

Gene expression profiling of the leading edge of cutaneous squamous cell carcinoma (SCC): IL-24 driven MMP-7
por: Mitsui, Hiroshi, et al.
Publicado: (2013)

Putting together the psoriasis puzzle: an update on developing targeted therapies
por: Johnson-Huang, Leanne M., et al.
Publicado: (2012)

Expression of IL-20 in synovium and lesional skin of patients with psoriatic arthritis: differential response to alefacept treatment
por: Lebre, Maria C, et al.
Publicado: (2012)

Combined Use of Laser Capture Microdissection and cDNA Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions
por: Mitsui, Hiroshi, et al.
Publicado: (2012)

Deep Sequencing of the T-cell Receptor Repertoire Demonstrates Polyclonal T-cell Infiltrates in Psoriasis
por: Harden, Jamie L., et al.
Publicado: (2015)

Identification of anaplastic lymphoma kinase as a potential therapeutic target in Basal Cell Carcinoma
por: Ning, Hanna, et al.
Publicado: (2013)

Exhausted-like CD8(+) T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects
por: Diggins, Kirsten E., et al.
Publicado: (2021)

The Histology of Psoriasis
por: Jamieson, W. Allan
Publicado: (1879)

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
por: Zaba, Lisa C., et al.
Publicado: (2008)

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
por: Zaba, Lisa C., et al.
Publicado: (2007)

Psoriasis vulgaris flare during efalizumab therapy does not preclude future use: a case series
por: Lowes, Michelle A, et al.
Publicado: (2005)

Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature
por: Hoffman, Lauren K., et al.
Publicado: (2018)

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis
por: Krueger, James G., et al.
Publicado: (2015)

Multi-TGDR: A Regularization Method for Multi-Class Classification in Microarray Experiments
por: Tian, Suyan, et al.
Publicado: (2013)

Comparative Genomic Profiling of Synovium Versus Skin Lesions in Psoriatic Arthritis
por: Belasco, Jennifer, et al.
Publicado: (2015)

Suppression of Molecular Inflammatory Pathways by Toll-Like Receptor 7, 8, and 9 Antagonists in a Model of IL-23-Induced Skin Inflammation
por: Suárez-Fariñas, Mayte, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_jsquj71shthqcd1jj4g5se4e98