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Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation
BACKGROUND: MRE11 is an important nuclease which functions in the end-resection step of homologous recombination (HR) repair of DNA double-strand breaks (DSBs). As MRE11-deficient ATLD cells exhibit hyper radio-sensitivity and impaired DSB repair, MRE11 inhibitors could possibly function as potent r...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831819/ https://www.ncbi.nlm.nih.gov/pubmed/20144237 http://dx.doi.org/10.1186/1476-4598-9-34 |