Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation

BACKGROUND: MRE11 is an important nuclease which functions in the end-resection step of homologous recombination (HR) repair of DNA double-strand breaks (DSBs). As MRE11-deficient ATLD cells exhibit hyper radio-sensitivity and impaired DSB repair, MRE11 inhibitors could possibly function as potent r...

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Detalles Bibliográficos
Autores principales: Kobayashi, Junya, Kato, Akihiro, Ota, Yosuke, Ohba, Reiko, Komatsu, Kenshi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831819/
https://www.ncbi.nlm.nih.gov/pubmed/20144237
http://dx.doi.org/10.1186/1476-4598-9-34

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