Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone

Niemann-Pick C disease (NPC) is an autosomal recessive neurodegenerative disorder caused by the abnormal function of NPC1 or NPC2 proteins, leading to an accumulation of unesterified cholesterol and glycosphingolipids (GSLs) in the lysosomes. The mechanisms underlying the pathophysiology in NPC dise...

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Detalles Bibliográficos
Autores principales: Zampieri, Stefania, Mellon, Synthia H, Butters, Terry D, Nevyjel, Marco, Covey, Douglas F, Bembi, Bruno, Dardis, Andrea
Formato: Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2009
Materias:
Molecular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832077/
https://www.ncbi.nlm.nih.gov/pubmed/18774957
http://dx.doi.org/10.1111/j.1582-4934.2008.00493.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832077/
https://www.ncbi.nlm.nih.gov/pubmed/18774957
http://dx.doi.org/10.1111/j.1582-4934.2008.00493.x

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