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Diversity of protein structures and difficulties in fold recognition: the curious case of protein G

We examine the ability of current state-of-the-art methods in protein structure prediction to discriminate topologically distant folds encoded by highly similar (>90% sequence identity) designed proteins in blind protein structure prediction experiments. We detail the corresponding prognosis for...

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Detalles Bibliográficos
Autores principales: Horst, Jeremy, Samudrala, Ram
Formato: Texto
Lenguaje:English
Publicado: Biology Reports Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832337/
https://www.ncbi.nlm.nih.gov/pubmed/20209018
http://dx.doi.org/10.3410/B1-69