Diversity of protein structures and difficulties in fold recognition: the curious case of protein G

We examine the ability of current state-of-the-art methods in protein structure prediction to discriminate topologically distant folds encoded by highly similar (>90% sequence identity) designed proteins in blind protein structure prediction experiments. We detail the corresponding prognosis for...

Descripción completa

Detalles Bibliográficos
Autores principales: Horst, Jeremy, Samudrala, Ram
Formato: Texto
Lenguaje:English
Publicado: Biology Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832337/
https://www.ncbi.nlm.nih.gov/pubmed/20209018
http://dx.doi.org/10.3410/B1-69
_version_ 1782178318521466880
author Horst, Jeremy
Samudrala, Ram
author_facet Horst, Jeremy
Samudrala, Ram
author_sort Horst, Jeremy
collection PubMed
description We examine the ability of current state-of-the-art methods in protein structure prediction to discriminate topologically distant folds encoded by highly similar (>90% sequence identity) designed proteins in blind protein structure prediction experiments. We detail the corresponding prognosis for the protein fold recognition field and highlight the features of the methodologies that successfully deciphered this folding riddle.
format Text
id pubmed-2832337
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Biology Reports Ltd
record_format MEDLINE/PubMed
spelling pubmed-28323372010-09-14 Diversity of protein structures and difficulties in fold recognition: the curious case of protein G Horst, Jeremy Samudrala, Ram F1000 Biol Rep Review Article We examine the ability of current state-of-the-art methods in protein structure prediction to discriminate topologically distant folds encoded by highly similar (>90% sequence identity) designed proteins in blind protein structure prediction experiments. We detail the corresponding prognosis for the protein fold recognition field and highlight the features of the methodologies that successfully deciphered this folding riddle. Biology Reports Ltd 2009-09-08 /pmc/articles/PMC2832337/ /pubmed/20209018 http://dx.doi.org/10.3410/B1-69 Text en © 2009 Biology Reports Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Horst, Jeremy
Samudrala, Ram
Diversity of protein structures and difficulties in fold recognition: the curious case of protein G
title Diversity of protein structures and difficulties in fold recognition: the curious case of protein G
title_full Diversity of protein structures and difficulties in fold recognition: the curious case of protein G
title_fullStr Diversity of protein structures and difficulties in fold recognition: the curious case of protein G
title_full_unstemmed Diversity of protein structures and difficulties in fold recognition: the curious case of protein G
title_short Diversity of protein structures and difficulties in fold recognition: the curious case of protein G
title_sort diversity of protein structures and difficulties in fold recognition: the curious case of protein g
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832337/
https://www.ncbi.nlm.nih.gov/pubmed/20209018
http://dx.doi.org/10.3410/B1-69
work_keys_str_mv AT horstjeremy diversityofproteinstructuresanddifficultiesinfoldrecognitionthecuriouscaseofproteing
AT samudralaram diversityofproteinstructuresanddifficultiesinfoldrecognitionthecuriouscaseofproteing

Ejemplares similares