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Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with cardiovascular traits

BACKGROUND: Conserved non-coding regions (CNR) have been shown to harbor gene expression regulatory elements. Genetic variations in these regions may potentially contribute to complex disease susceptibility. METHODS: We targeted CNRs of cardiovascular disease (CVD) candidate gene, Na(+)-Ca(2+) excha...

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Detalles Bibliográficos
Autores principales: Kepp, Katrin, Org, Elin, Sõber, Siim, Kelgo, Piret, Viigimaa, Margus, Veldre, Gudrun, Tõnisson, Neeme, Juhanson, Peeter, Putku, Margus, Kindmark, Andreas, Kožich, Viktor, Laan, Maris
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832636/
https://www.ncbi.nlm.nih.gov/pubmed/20109173
http://dx.doi.org/10.1186/1471-2350-11-15